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T cells play a central role in the adaptive immune response continuously surveying and responding to cellular abnormalities and pathogens / infections. T cells are generated by the thymus largely in early life and then maintained throughout adult life by complex homeostatic mechanisms. Both T cell homeostasis and pathogen induced T cell activation are reliant on T cells engaging and responding to self and foreign peptide antigens respectively via cell surface T cell receptors (TCRs). The resultant level of TCR signalling is key to ensuring that the responses to high affinity foreign antigens are robust and that pathogens and infected cells are eliminated effectively, whereas responses to lower affinity self antigens blackhawks jersey are restricted, allowing for T cell survival and division (under conditions of lymphopenia), whilst preventing excessive responses and the development of autoimmunity.

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